Pharmacokinetic Properties (part 4 of 4)
The therapeutic effect of each preparation is conditioned by its absorption (intestinal or pulmonary) and by the specific metabolites produced within the human body. Important is the difference between oral and inhalation preparations. In fact, inhaled cannabinoids and terpenes arrive via the lungs directly into the blood stream, whereas the absorption of ingested compounds is […]
Pharmaceutical forms and mode of intake (part 3 of 4)
ABSTRACT Pharmacists play a crucial role in preparing medical cannabis in accordance with established regulations and guidelines. By following the Norms of Good Preparation (NBP), pharmacists create magistral preparations of cannabis, ensuring the distribution of the active substance in the appropriate dose and medication form, as prescribed by doctors. The administration of medical cannabis involves […]
Production according to GACP and GMP (part 2 of 4)
ABSTRACT Standardized compositions are vital for medicines, especially in the case of phytopharmaceuticals like cannabis. Precise control of cultivation conditions is crucial as the composition of cannabis, including cannabinoids and terpenes, determines its medicinal properties. Even slight changes can significantly impact therapeutic potential hence, rigorous quality control is essential to ensure reliability. These meticulous measures […]
Chemotypes of cannabis (part 1 of 4)
ABSTRACT Cannabis sativa is a dioecious plant that is widely distributed in areas with a temperate climate. The plant has three main varieties, each with its own chemical and morphological characteristics: hemp (Cannabis sativa), Indian hemp (Cannabis indica), and Russian or American hemp (Cannabis ruderalis). The chemical compounds produced by cannabis, known as secondary metabolites, […]
Legislative panorama: focus on Italy
Internationallly speaking, there are two United Nations conventions regulating the import, distribution, marketing, sale, production and preparation of narcotic substances: one promulgated in 1961 and the other in 1971, both ratified by Italy. Among the substances affected by these regulations is cannabis, which is further regulated by Italian legislation through Table II of the Consolidated […]
